Biomarkers of vascular function in premenopausal and recent postmenopausal women of similar age: effect of exercise training.
نویسندگان
چکیده
Menopause is associated with an accelerated decline in vascular function; however, whether this is an effect of age and/or menopause and how exercise training may affect this decline remains unclear. We examined a range of molecular measures related to vascular function in matched premenopausal and postmenopausal women before and after 12 wk of exercise training. Thirteen premenopausal and 10 recently postmenopausal [1.6 ± 0.3 (means ± SE) years after final menstrual period] women only separated by 3 yr (48 ± 1 vs. 51 ± 1 yr) were included. Before training, diastolic blood pressure, soluble intercellular adhesion molecule-1 (sICAM-1), and skeletal muscle expression of thromboxane A synthase were higher in the postmenopausal women compared with the premenopausal women, all indicative of impaired vascular function. In both groups, exercise training lowered diastolic blood pressure, the levels of sICAM-1, soluble vascular adhesion molecule-1 (sVCAM-1), as well as plasma and skeletal muscle endothelin-1. The vasodilator prostacyclin tended (P = 0.061) to be higher in plasma with training in the postmenopausal women only. These findings demonstrate that already within the first years after menopause, several biomarkers of vascular function are adversely altered, indicating that these biomarker changes are more related to hormonal changes than aging. Exercise training appears to have a positive impact on vascular function, as indicated by a marked improvement in the biomarker profile, in both premenopausal and postmenopausal women.
منابع مشابه
Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase.
KEY POINTS Exercise training effectively improves vascular and skeletal muscle function; however, these effects of training may be blunted in postmenopausal women as a result of the loss of oestrogens. Accordingly, the capacity to deliver oxygen to the active muscles may also be impaired in postmenopausal women. In both premenopausal and recent postmenopausal women, exercise training was shown ...
متن کاملEarly Postmenopausal Phase Is Associated With Reduced Prostacyclin-Induced Vasodilation That Is Reversed by Exercise Training: The Copenhagen Women Study.
The postmenopausal phase is associated with an accelerated rate of rise in the prevalence of vascular dysfunction and hypertension; however, the mechanisms underlying these adverse vascular changes and whether exercise training can reverse the decline in vascular function remains unclear. We examined the function of the vascular prostanoid system in matched pre- and postmenopausal women before ...
متن کاملEarly Postmenopausal Phase Is Associated With Reduced Prostacyclin-Induced Vasodilation That Is Reversed by Exercise Training
The postmenopausal phase is associated with an accelerated rate of rise in the prevalence of endothelial dysfunction and hypertension and the incidence of cardiovascular disease is also higher in postmenopausal than in premenopausal women of similar age. Although much is known about the beneficial effects of estrogen on vascular function, the mechanisms by which changes in the hormonal environm...
متن کاملاثر یک دوره تمرین هوازی بر شاخص‌های عملکرد اندوتلیالی زنان یائسه مبتلا به پرفشار خونی
Background & Aims : Aging and the loss of endogenous estrogen production after menopause are accompanied by increases in blood pressure and endothelial dysfunction. Exercise training improves endothelial function in patients with hypertension. The aim of this study was to examine the effect of aerobic training on some markers of endothelial function in hypertensive postmenopausal women. M...
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عنوان ژورنال:
- American journal of physiology. Regulatory, integrative and comparative physiology
دوره 306 7 شماره
صفحات -
تاریخ انتشار 2014